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Article

Molecular chaperone disorders: defective Hsp60 in neurodegeneration.

Current topics in medicinal chemistry - 1 Jan 2012

Bross Peter, Magnoni Raffaella, Bie Anne Sigaard

Abstract excerpt

Chaperonins, a subgroup of molecular chaperones, form ring-shaped structures and assist folding of proteins by enclosing them in their inner cavity. The mitochondrial Hsp60/Hsp10 chaperonin system is essential for cell viability and only a very small number of mutations causing human disease have so far been found that appear to selectively affect neuronal tissues. We here review the knowledge on the mammalian...

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PMID: 23339303
DOI: 10.2174/1568026611212220005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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