Article
Parallel evolution of two distinct lymphoid proliferations in clonal haematopoiesis.
Histopathology - 1 Apr 2022
Attygalle Ayoma D, Dobson Rachel, Chak Pui Kwan, Vroobel Katherine M, Wren Dorte, Mugalaasi Hood, Morgan Yvonne, Kaur Manmit, Ahmad Raida, Chen Zi, Naresh Kikkeri N, Du Ming-Qing
Abstract excerpt
AIMS: Angioimmunoblastic T-cell lymphoma (AITL) is genetically characterized by TET2 and DNMT3A mutations occurring in haematopoietic progenitor cells, and late events (e.g. the RHOA-G17V mutation) associated with malignant transformation. As TET2/DNMT3A-mutated progenitor cells can differentiate into multilineage progenies and give rise to both AITL and myeloid neoplasms, they may also have the potential to lead...
Topics
- Aged
- CD8 Antigens
- Cell Proliferation
- Clonal Hematopoiesis
- DNA Methyltransferase 3A
- DNA-Binding Proteins
- Diagnosis, Differential
- Dioxygenases
- Female
- Humans
- Immunoblastic Lymphadenopathy
- Lymphoma, T-Cell
- Male