Article
TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphoma.
The Journal of pathology - 1 Jun 2017
Schwartz Friederike H, Cai Qian, Fellmann Eva, Hartmann Sylvia, Mäyränpää Mikko I, Karjalainen-Lindsberg Marja-Liisa, Sundström Christer, Scholtysik René, Hansmann Martin-Leo, Küppers Ralf
Abstract excerpt
Angioimmunoblastic T-cell lymphomas (AITLs) frequently carry mutations in the TET2 and IDH2 genes. TET2 mutations represent early genetic lesions as they had already been detected in haematopoietic precursor cells of AITL patients. We show by analysis of whole-tissue sections and microdissected PD1+ cells that the frequency of TET2-mutated AITL is presumably even higher than reported (12/13 cases in our...
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