Article

Single-cell gene programs define subtype identity and metastatic trajectories in renal cell carcinoma

2026-07-16

Abstract excerpt

While extensive cellular heterogeneity in renal cell carcinomas (RCC) is linked to diverse clinical outcomes, our understanding of this diversity is limited to those driven by clonal patterns or activity of canonical pathways. Here, we present a compendium of over 85,000 single-cell gene expression profiles from primary and metastatic tumors as well as patient-derived models across four RCC subtypes, including the...

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Literature Corpus work: bea7cc2b-f807-57a0-88b3-fa74debfe822
DOI: 10.64898/2026.07.14.26357682

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