Article

Clear cell renal cell carcinoma consensus transcriptomic programs reveal converging trajectories towards aggressive disease

2026-06-26

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is characterized by a branching genomic trajectory in which early biallelic VHL inactivation splits into PBRM1 - and BAP1 -mutant lineages. However, driver mutations alone do not account for the molecular and phenotypic heterogeneity. To dissect this heterogeneity, we developed a non-negative matrix factorization (NMF)-based gene expression analytical framework for identi...

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Literature Corpus work: 2a67d719-a9c9-55d0-a369-d1d922fab10c
DOI: 10.64898/2026.06.24.734364

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