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Article

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

18 Dec 2019

Abstract excerpt

Cancer is a hyper-proliferative disease. Whether the proliferative state originates from the cell-of-origin or emerges later remains difficult to resolve. By tracking de novo transformation from normal hematopoietic progenitors expressing an acute myeloid leukemia (AML) oncogene MLL-AF9, we reveal that the cell cycle rate heterogeneity among granulocyte-macrophage progenitors (GMPs) determines their probability...

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PMID: 31852898
DOI: 10.1038/s41467-019-13666-5

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