Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients.

doi:10.3390/ijms21083025

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Article

Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients.

International journal of molecular sciences - 24 Apr 2020

Geissler Klaus, Jäger Eva, Barna Agnes, Gurbisz Michael, Graf Temeida, Graf Elmir, Nösslinger Thomas, Pfeilstöcker Michael, Tüchler Heinz, Sliwa Thamer, Keil Felix, Geissler Christoph, Heibl Sonja, Thaler Josef, Machherndl-Spandl Sigrid, Zach Otto, Weltermann Ansgar, Bettelheim Peter, Stauder Reinhard, Zebisch Armin, Sill Heinz, Schwarzinger Ilse, Schneeweiss Bruno, Öhler Leopold, Ulsperger Ernst, Kusec Rajko, Germing Ulrich, Sperr Wolfgang R, Knöbl Paul, Jäger Ulrich, Hörmann Gregor, Valent Peter

Abstract excerpt

Although the RAS-pathway has been implicated as an important driver in the pathogenesis of chronic myelomonocytic leukemia (CMML) a comprehensive study including molecular and functional analyses in patients with progression and transformation has not been performed. A close correlation between RASopathy gene mutations and spontaneous in vitro myeloid colony (CFU-GM) growth in CMML has been described. Molecular...

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PMID: 32344757
DOI: 10.3390/ijms21083025
PMCID: PMC7215883

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Source receipt: pubmed, retrieved 6 Sept 2026.

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