Article

MLL-AF9 Initiates Transformation From Fast-Proliferating Myeloid Progenitors

2018-11-30

Abstract excerpt

Cancer is a hyper-proliferative clonal disease. Whether the proliferative state originates from the cell-of-origin or emerges later remains elusive. By tracking de novo transformation from normal hematopoietic progenitors expressing an acute myeloid leukemia (AML) oncogene MLL-AF9, we reveal that the cell cycle rate heterogeneity among granulocyte-macrophage progenitors (GMPs) determines their probability of tran...

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Literature Corpus work: 2aff7639-aa88-597b-865a-5caf6c444266
DOI: 10.1101/484220

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