Article

NPMc+ and Flt3-ITD cooperation promotes a new oncogenic HSC state that supports transformation and leukemia stem cell maintenance

2024-07-26

Abstract excerpt

NPMc+ and FLT3-ITD are the most frequently co-occurring mutations in Acute Myeloid Leukemia (AML). Cellular and molecular mechanisms of their cooperation are largely unknown. We investigated their effects on pre-leukemic and leukemic hematopoietic stem cells (HSCs) in mouse models that recapitulate the human disease. Both oncogenes increase proliferation of pre-leukemia HSCs, however, only NPMc+ extends self-renew...

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Literature Corpus work: 376d854e-7709-5f33-8e0f-b6b54b06a098
DOI: 10.1101/2024.07.25.605115

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