Article

A cutting-edge approach unravels a novel role for CDK6 in leukemic progenitor cells

2020-10-05

Abstract excerpt

Studies of molecular mechanisms of hematopoiesis and leukemogenesis are hampered by the unavailability of progenitor cell lines that accurately mimic the situation in vivo . We now report a robust method to generate and maintain LSK (lin - , Sca-1 + , c-Kit + ) cells which closely resemble MPP1 cells. HPC LSK reconstitute hematopoiesis in lethally irradiated recipient mice over more than eight months. Upon tr...

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Literature Corpus work: fde16fc0-324d-5ba6-af38-dc743e636bce
DOI: 10.1101/2020.10.05.325886

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