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Article

Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease.

Annals of the rheumatic diseases - 1 Mar 2020

Attur Mukundan, Zhou Hua, Samuels Johathan, Krasnokutsky Svetlana, Yau Michelle, Scher Jose U, Doherty Michael, Wilson Anthony G, Bencardino Jenny, Hochberg Marc, Jordan Joanne M, Mitchell Braxton, Kraus Virginia B, Abramson Steven B

Abstract excerpt

OBJECTIVE: In these studies, we examined the association of single nucleotide polymorphisms (SNPs) of the IL1RN gene with radiographic severity of symptomatic knee osteoarthritis (SKOA) and the risk of incident OA. We also explored these genetic polymorphisms in patients with new onset rheumatoid arthritis (RA). METHODS: Over 1000 subjects who met American College of Rheumatology criteria for tibiofemoral OA were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31852669
DOI: 10.1136/annrheumdis-2019-216055
PMCID: PMC7034355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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