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Article

Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study.

Arthritis and rheumatism - 1 Apr 2010

Meulenbelt Ingrid, Bos Steffan D, Kloppenburg Margreet, Lakenberg Nico, Houwing-Duistermaat Jeanine J, Watt Iain, de Craen Anton J, van Duijn Cornelia M, Slagboom P Eline

Abstract excerpt

OBJECTIVE: To assess whether genetic variation in the interleukin-1 (IL-1) gene cluster contributes to familial osteoarthritis (OA) by influencing innate ex vivo production of IL-1beta or IL-1 receptor antagonist (IL-1Ra). METHODS: Innate ex vivo IL-1beta and IL-1Ra production upon lipopolysaccha...

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PMID: 20131253
DOI: 10.1002/art.27325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20131253-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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