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Article

Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty.

Arthritis and rheumatism - 1 Oct 2008

Gordon Andrew, Kiss-Toth E, Stockley Ian, Eastell Richard, Wilkinson J Mark

Abstract excerpt

OBJECTIVE: To determine whether osteolysis after total hip arthroplasty (THA) is associated with common polymorphisms within the genes encoding the interleukin-1 (IL-1) family and IL-6, and to determine whether polymorphisms that are associated with osteolysis affect in vitro messenger RNA (mRNA) expression in human peripheral blood mononuclear cells (PBMCs) in response to wear particles. METHODS: Unrelated white...

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Identifiers

PMID: 18821666
DOI: 10.1002/art.23863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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