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Article

Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis.

Genes and immunity - 1 Sept 2004

Smith A J P, Keen L J, Billingham M J, Perry M J, Elson C J, Kirwan J R, Sims J E, Doherty M, Spector T D, Bidwell J L

Abstract excerpt

The interleukin-1 gene cluster is a key regulator in a number of chronic disease processes. We explored the linkage between nine polymorphic loci in the IL1R1 promoter, eight in the IL1A-IL1B-IL1RN gene complex, and their association with osteoarthritis (OA), a common complex disease associated with low-level inflammation. Using 195 healthy controls, we identified eight novel polymorphisms in the IL1R1 exon 1A...

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Identifiers

PMID: 15190266
DOI: 10.1038/sj.gene.6364107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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