Article
Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.
Annals of the rheumatic diseases - 1 May 2010
Attur Mukundan, Wang Hwa-Ying, Kraus Virginia Byers, Bukowski Jack F, Aziz Nazneen, Krasnokutsky Svetlana, Samuels Jonathan, Greenberg Jeffrey, McDaniel Gary, Abramson Steven B, Kornman Kenneth S
Abstract excerpt
BACKGROUND: A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. OBJECTIVE: To determine whether inflammatory genetic markers could stratify patients with knee OA into high and low risk for destructive disease. M...
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