Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-1 receptor antagonist gene polymorphisms are associated with disease severity in Black South Africans with rheumatoid arthritis.

Joint bone spine - 1 Jul 2008

Lubbe Steven, Tikly Mohammed, van der Merwe Lize, Hodkinson Bridget, Ramsay Michele

Abstract excerpt

OBJECTIVE: To test for genetic associations between polymorphisms of the interleukin-1 (IL-1) gene cluster and disease susceptibility and severity in Black South Africans with rheumatoid arthritis (RA). METHODS: Allele and genotype frequencies of IL1B (-511) and (+3954) and IL1RN variable number of tandem repeat (VNTR) and (+2018) were compared between 141 RA patients and 101 healthy controls. RESULTS: No...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Black People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Interleukin 1 Receptor Antagonist Protein

Share to Interleukin-1beta

Share to Severity of Illness Index

Share to South Africa

Share to Tandem Repeat Sequences

Source

Identifiers

PMID: 18468936
DOI: 10.1016/j.jbspin.2007.09.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-1 receptor antagonist gene polymorphisms are associated with disease severity in Black South Africans with rheumatoid arthritis.PMID 18468936Read ↗

Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.Semantic proximity Read ↗

Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease.Semantic proximity Read ↗

Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts.Semantic proximity Read ↗

Interleukin–1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosusSemantic proximity Read ↗

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.Semantic proximity Read ↗

Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis.Semantic proximity Read ↗

Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?Semantic proximity Read ↗

Relationship of polymorphisms of the Interleukin-1 gene cluster to occurrence and severity of rheumatoid arthritis.Semantic proximity Read ↗

Association of interleukin-4 and interleukin-1B gene variants with Larsen score progression in rheumatoid arthritis.Semantic proximity Read ↗

Investigation of Caucasian rheumatoid arthritis susceptibility loci in African patients with the same disease.Semantic proximity Read ↗

The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis.Semantic proximity Read ↗

IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.