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Article

IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort.

Osteoarthritis and cartilage - 1 Jul 2013

Wu X, Kondragunta V, Kornman K S, Wang H Y, Duff G W, Renner J B, Jordan J M

Abstract excerpt

OBJECTIVE: Within the interleukin-1 (IL-1) cytokine family, IL-1 receptor antagonist (IL1RN) gene variants have been associated with radiological severity of knee osteoarthritis (OA) in cross-sectional studies. The present study tested the relation between IL1RN gene variants and progression of knee OA assessed radiographically by change in Kellgren-Lawrence (KL) score over time. DESIGN: 1153 Caucasian adults...

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Identifiers

PMID: 23602982
DOI: 10.1016/j.joca.2013.04.003
PMCID: PMC3725144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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