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Article

Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation.

Cell reports - 17 Dec 2019

Senigl Filip, Maman Yaakov, Dinesh Ravi K, Alinikula Jukka, Seth Rashu B, Pecnova Lubomira, Omer Arina D, Rao Suhas S P, Weisz David, Buerstedde Jean-Marie, Aiden Erez Lieberman, Casellas Rafael, Hejnar Jiri, Schatz David G

Abstract excerpt

Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. We have used lentiviral SHM reporter vectors to identify regions of the genome that are susceptible ("hot") and resistant ("cold") to SHM, revealing that SHM susceptibility and resistance are often properties of entire topologically associated domains (TADs). Comparison of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31851922
DOI: 10.1016/j.celrep.2019.11.039
PMCID: PMC6980758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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