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Selective Enhancer Dependencies in <i>MYC</i> -Intact and <i>MYC</i> -Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma

2023-05-03

Abstract excerpt

High expression of MYC and its target genes define a subset of germinal center B-cell diffuse large B-cell lymphoma (GCB-DLBCL) associated with poor outcomes. Half of these high-grade cases show chromosomal rearrangements between the MYC locus and heterologous enhancer-bearing loci, while focal deletions of the adjacent non-coding gene PVT1 are enriched in MYC -intact cases. To identify genomic drivers of MYC...

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Literature Corpus work
e4029be5-82fa-5c80-978a-3e2fc643c74b
DOI
10.1101/2023.05.02.538892
Open publication

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Selective Enhancer Dependencies in <i>MYC</i> -Intact and <i>MYC</i> -Rearranged Germinal Center B-cell Diffuse Large B-cell LymphomaDOI 10.1101/2023.05.02.538892
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