KSHV Topologically Associating Domains in Latent and Reactivated Viral Chromatin

Abstract excerpt

Eukaryotic genomes are structurally organized via the formation of multiple loops that create gene expression regulatory units called topologically associating domains (TADs). Here we revealed the KSHV TAD structure at 500 base pair resolution and constructed a 3D KSHV genomic structural model with 2kb binning. The latent KSHV genome formed very similar genomic architectures in three different naturally infected P...

Topics

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• Cancer-related molecular mechanisms research
• Cytomegalovirus and herpesvirus research
• Herpesvirus Infections and Treatments
• Histiocytic Disorders and Treatments
• HIV Research and Treatment
• RNA modifications and cancer
• T-cell and Retrovirus Studies
• Viral-associated cancers and disorders

Identifiers and source

Literature Corpus work

fb9d7608-3e51-531d-8efa-5e35fd010f0d

DOI

10.1101/2022.04.05.487244