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Article

MeinteR: A framework to prioritize DNA methylation aberrations based on conformational and cis-regulatory element enrichment.

Scientific reports - 16 Dec 2019

Malousi Andigoni, Kouidou Sofia, Tsagiopoulou Maria, Papakonstantinou Nikos, Bouras Emmanouil, Georgiou Elisavet, Tzimagiorgis Georgios, Stamatopoulos Kostas

Abstract excerpt

DNA methylation studies have been reformed with the advent of single-base resolution arrays and bisulfite sequencing methods, enabling deeper investigation of methylation-mediated mechanisms. In addition to these advancements, numerous bioinformatics tools address important computational challenges, covering DNA methylation calling up to multi-modal interpretative analyses. However, contrary to the analytical...

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PMID: 31844073
DOI: 10.1038/s41598-019-55453-8
PMCID: PMC6915744

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