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Article

The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.

The Journal of biological chemistry - 24 Jan 2020

Jureka Alexander S, Kleinpeter Alex B, Tipper Jennifer L, Harrod Kevin S, Petit Chad M

Abstract excerpt

A critical role of influenza A virus nonstructural protein 1 (NS1) is to antagonize the host cellular antiviral response. NS1 accomplishes this role through numerous interactions with host proteins, including the cytoplasmic pathogen recognition receptor, retinoic acid-inducible gene I (RIG-I). Although the consequences of this interaction have been studied, the complete mechanism by which NS1 antagonizes RIG-I...

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Identifiers

PMID: 31843969
DOI: 10.1074/jbc.RA119.011410
PMCID: PMC6983837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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