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Article

Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2

1 Mar 2021

Abstract excerpt

Human respiratory syncytial virus (RSV) nonstructural protein 2 (NS2) inhibits host interferon (IFN) responses stimulated by RSV infection by targeting early steps in the IFN-signaling pathway. But the molecular mechanisms related to how NS2 regulates these processes remain incompletely understood. To address this gap, here we solved the X-ray crystal structure of NS2. This structure revealed a unique fold that...

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PMID: 33649232
DOI: 10.1073/pnas.2020587118

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