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Article

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

2 May 2018

Abstract excerpt

RIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin chains, synthesised by TRIM25, is crucial for activation of the RIG-I/MAVS signalling pathway. TRIM25 activity is targeted by influenza A virus non-structural protein 1 (NS1) to suppress IFN production and prevent an efficient...

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PMID: 29739942
DOI: 10.1038/s41467-018-04214-8

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