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Article

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.

Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2008

Gack Michaela U, Kirchhofer Axel, Shin Young C, Inn Kyung-Soo, Liang Chengyu, Cui Sheng, Myong Sua, Ha Taekjip, Hopfner Karl-Peter, Jung Jae U

Abstract excerpt

The caspase recruitment domain (CARD) of intracellular adaptors and sensors plays a critical role in the assembly of signaling complexes involved in innate host defense against pathogens and in the regulation of inflammatory responses. The cytosolic receptor retinoic acid-inducible gene-I (RIG-I) recognizes viral RNA in a 5'-triphosphate-dependent manner and initiates an antiviral signaling cascade. Upon viral...

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Source

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Identifiers

PMID: 18948594
DOI: 10.1073/pnas.0804947105
PMCID: PMC2575490

Genes

TRIM25
MAVS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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