Article

Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State

2026-03-06

Abstract excerpt

<h4>ABSTRACT</h4> RIG-I is a cytosolic immune receptor that provides the first line of defense by detecting viral RNA and triggering antiviral responses. Its physiological role in humans remains unclear, as no patients with complete RIG-I deficiency have yet been reported. We identified a critically ill COVID-19 patient with severe RIG-I deficiency caused by heterozygous RIG-I G731R, a novel dominant loss-of-func...

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Identifiers and source

Literature Corpus work: cbe9406b-156b-55fa-a2c5-aca3fd4c6ac3
DOI: 10.64898/2026.03.02.26347088

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