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Article

Clonal hematopoiesis as a model for premalignant changes during aging.

Experimental hematology - 1 Mar 2020

Steensma David P, Ebert Benjamin L

Abstract excerpt

Over the course of the human life span, somatic DNA mutations accumulate in healthy tissues. This process has been most clearly described in blood and bone marrow, esophagus, colon, and skin, but cumulative DNA damage likely affects all tissues of the body. Although most acquired genetic variants have no discernable functional consequences, some randomly occurring somatic mutations confer a relative fitness...

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Identifiers

PMID: 31838005
DOI: 10.1016/j.exphem.2019.12.001
PMCID: PMC7103509

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