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Variation in cancer risk between organs can not be explained by the degree of somatic clonal expansion

23 May 2024

Abstract excerpt

Somatic clonal expansion refers to the proliferation and expansion of a cell clone within a multicellular organism. Since cancer also results from the uncontrolled proliferation of few cell clones, it is generally believed that aging-associated somatic clonal expansion observed in normal tissues represents a precancerous condition. For instance, hematological malignancy is often preceded by clonal hematopoiesis....

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PMID: 39883325
DOI: 10.1007/s44307-024-00025-9

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