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Article

Aging, clonal hematopoiesis and preleukemia: not just bad luck?

International journal of hematology - 1 Nov 2015

Shlush Liran I, Zandi Sasan, Itzkovitz Shalev, Schuh Andre C

Abstract excerpt

Chronological human aging is associated with a number of changes in the hematopoietic system, occurring at many levels from stem to mature cells, and the marrow microenvironment as well. This review will focus mainly on the aging of hematopoietic stem and progenitor cells (HSPCs), and on the associated increases in the incidence of hematological malignancies. HSPCs manifest reduced function and acquire molecular...

Topics

Aging
Hematopoiesis
Hematopoietic Stem Cells
Humans
Leukemia
Mutation
Precancerous Conditions

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26440972
DOI: 10.1007/s12185-015-1870-5

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