Age-related clonal hematopoiesis.

doi:10.1182/blood-2017-07-746453

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Article

Age-related clonal hematopoiesis.

Blood - 1 Feb 2018

Shlush Liran I

Abstract excerpt

Age-related alterations in the human blood system occur in B cells, T cells, cells of the innate system, as well as hematopoietic stem and progenitor cells (HSPCs). Interestingly, age-related, reduced genetic diversity can be identified at the stem cell level and also independently in B cells and T cells. This reduced diversity is most probably related to somatic mutations or to changes in the microenvironmental...

Topics

Aging
Animals
Clonal Evolution
Clone Cells
Genetic Variation
Hematologic Neoplasms
Hematopoiesis
Hematopoietic Stem Cells
Humans

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Open in PubMed

Identifiers

PMID: 29141946
DOI: 10.1182/blood-2017-07-746453

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