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Article

Clonal hematopoiesis, somatic mosaicism, and age-associated disease.

Physiological reviews - 1 Jan 2023

Evans Megan A, Walsh Kenneth

Abstract excerpt

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the same tissue, is an evitable consequence of human aging. The hematopoietic system is no exception to this, where studies have revealed the presence of expanded blood cell clones carrying mutations in preleukemic driver genes and/or genetic alterations in chromosomes. This phenomenon is referred to as clonal hematopoiesis and...

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Identifiers

PMID: 36049115
DOI: 10.1152/physrev.00004.2022
PMCID: PMC9639777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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