Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic interaction is associated with lower metabolic connectivity and memory impairment in clinically mild Alzheimer's disease.

Genes, brain, and behavior - 1 Jun 2019

Chang Y-T, Huang C-W, Huang S-H, Hsu S-W, Chang W-N, Lee J-J, Chang C-C

Abstract excerpt

Metabolic connectivity as showed by [18F] fluorodeoxyglucose (FDG) positron emission tomography (FDG-PET) reflects neuronal connectivity. The aim of this study was to investigate the genetic impact on metabolic connectivity in default mode subnetworks and its clinical-pathological relationships in patients with Alzheimer's disease (AD). We separately investigated the modulation of 2 default mode subnetworks, as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Connectome

Share to Magnetic Resonance Imaging

Share to Memory

Share to Monomeric Clathrin Assembly Proteins

Share to Positron-Emission Tomography

Source

Identifiers

PMID: 29883038
DOI: 10.1111/gbb.12490

Genes

APOE
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic interaction is associated with lower metabolic connectivity and memory impairment in clinically mild Alzheimer's disease.PMID 29883038Read ↗

Differential Effects of APOE Genotypes on the Anterior and Posterior Subnetworks of Default Mode Network in Amnestic Mild Cognitive Impairment.Semantic proximity Read ↗

Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.Semantic proximity Read ↗

Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults.Semantic proximity Read ↗

APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network.Semantic proximity Read ↗

Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP, presenilins and APOE ε4.Semantic proximity Read ↗

Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers.Semantic proximity Read ↗

Effect of PICALM rs3851179 polymorphism on the default mode network function in mild cognitive impairmentSemantic proximity Read ↗

ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer's disease.Semantic proximity Read ↗

Recognition memory is associated with altered resting-state functional connectivity in people at genetic risk for Alzheimer's disease.Semantic proximity Read ↗

The TT allele of rs405509 synergizes with APOE ε4 in the impairment of cognition and its underlying default mode network in non-demented elderly.Semantic proximity Read ↗

White matter dysfunction in Alzheimer’s disease is associated with disease-related transcriptomic signaturesSemantic proximity Read ↗

Multiple genetic imaging study of the association between cholesterol metabolism and brain functional alterations in individuals with risk factors for Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.