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Article

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology.

Acta neuropathologica communications - 12 Dec 2019

Joshi Amit U, Van Wassenhove Lauren D, Logas Kelsey R, Minhas Paras S, Andreasson Katrin I, Weinberg Kenneth I, Chen Che-Hong, Mochly-Rosen Daria

Abstract excerpt

Aldehyde dehydrogenase 2 deficiency (ALDH2*2) causes facial flushing in response to alcohol consumption in approximately 560 million East Asians. Recent meta-analysis demonstrated the potential link between ALDH2*2 mutation and Alzheimer's Disease (AD). Other studies have linked chronic alcohol consumption as a risk factor for AD. In the present study, we show that fibroblasts of an AD patient that also has an...

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Identifiers

PMID: 31829281
DOI: 10.1186/s40478-019-0839-7
PMCID: PMC6907112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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