Uncovering newly identified aldehyde dehydrogenase 2 genetic variants that lead to acetaldehyde accumulation after an alcohol challenge.

doi:10.1186/s12967-024-05507-x

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Article

Uncovering newly identified aldehyde dehydrogenase 2 genetic variants that lead to acetaldehyde accumulation after an alcohol challenge.

Journal of translational medicine - 29 Jul 2024

Rwere Freeborn, White Joseph R, Hell Rafaela C R, Yu Xuan, Zeng Xiaocong, McNeil Leslie, Zhou Kevin N, Angst Martin S, Chen Che-Hong, Mochly-Rosen Daria, Gross Eric R

Abstract excerpt

BACKGROUND: Aldehyde dehydrogenase 2 (ALDH2) is critical for alcohol metabolism by converting acetaldehyde to acetic acid. In East Asian descendants, an inactive genetic variant in ALDH2, rs671, triggers an alcohol flushing response due to acetaldehyde accumulation. As alcohol flushing is not exclusive to those of East Asian descent, we questioned whether additional ALDH2 genetic variants can drive facial...

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PMID: 39075523
DOI: 10.1186/s12967-024-05507-x
PMCID: PMC11288122

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ALDH2

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