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Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer’s disease

24 Aug 2023

Abstract excerpt

Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism in East Asians descent (called ALDH2*2 or E504K missense variant, SNP ID: rs671), present in approximately 8% of the world’s population, has been associated with a variety of diseases. Recent meta-analyses support the relationship between this...

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PMID: 37693648
DOI: 10.3389/fnagi.2023.1223977

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