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Article

Association Study and Meta-Analysis of Polymorphisms and Blood mRNA Expression of the ALDH2 Gene in Patients with Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2022

Ueno Mariko, Yoshino Yuta, Mori Hiroaki, Funahashi Yu, Kumon Hiroshi, Ochi Shinichiro, Ozaki Tomoki, Tachibana Ayumi, Yoshida Taku, Shimizu Hideaki, Mori Takaaki, Iga Jun-Ichi, Ueno Shu-Ichi

Abstract excerpt

BACKGROUND: Late-onset Alzheimer's disease (LOAD) is a complex disease in which neuroinflammation plays an important pathophysiological role, and exposure to neurotoxic substrates such as aldehydes may contribute. Blood mRNA expression levels of neuroinflammation-related genes appear to be potential biological markers of LOAD. A relationship between ALDH2 and LOAD has been suggested. OBJECTIVE: Our objective was...

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Share to Aldehyde Dehydrogenase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35404279
DOI: 10.3233/JAD-215627
PMCID: PMC9198735

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