Article
Mitochondrial ALDH2 deficiency as an oxidative stress.
Annals of the New York Academy of Sciences - 1 Apr 2004
Ohta Shigeo, Ohsawa Ikuroh, Kamino Kouzin, Ando Fujiko, Shimokata Hiroshi
Abstract excerpt
Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a major role in ethanol metabolism. It is involved in acetaldehyde detoxification. A polymorphism of the ALDH2 gene is specific to North-East Asians. Sensitivity to ethanol is highly associated with this polymorphism (ALDH2(*)2 allele), which is responsible for a deficiency of ALDH2 activity. We first show that this deficiency influences the risk for late-onset...
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