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PNA-Pdx: Versatile Peptide Nucleic Acid-Based Detection of Nucleic Acids and SNPs.

Analytical chemistry - 26 Sept 2023

Jiang Wenjun, Aman Rashid, Ali Zahir, Rao Gundra S, Mahfouz Magdy

Abstract excerpt

Monitoring diseases caused by pathogens or by mutations in DNA sequences requires accurate, rapid, and sensitive tools to detect specific nucleic acid sequences. Here, we describe a new peptide nucleic acid (PNA)-based nucleic acid detection toolkit, termed PNA-powered diagnostics (PNA-Pdx). PNA-Pdx employs PNA probes that bind specifically to a target and are then detected in lateral flow assays. This can...

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PMID: 37696750
DOI: 10.1021/acs.analchem.3c01809
PMCID: PMC10535012

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