Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice

10 Sept 2024

Abstract excerpt

Detection of cytosolic DNA by the cyclic GMP-AMP (cGAMP) synthase (cGAS)–stimulator of interferon genes (STING) pathway provides immune defense against pathogens and cancer but can also cause autoimmunity when overactivated. The exonuclease three prime repair exonuclease 1 (TREX1) degrades DNA in the cytosol and prevents cGAS activation by self-DNA. Loss-of-function mutations of the TREX1 gene are linked to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Viral Infections and Vectors
Share to Inflammasome and immune disorders
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39254994
DOI: 10.1073/pnas.2411747121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient micePMID 39254994Read ↗

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseasesSemantic proximity Read ↗

T Cells Produce IFN-α in the TREX1 D18N Model of Lupus-like AutoimmunitySemantic proximity Read ↗

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent MannerSemantic proximity Read ↗

TREX1 exonuclease in immunity and diseaseSemantic proximity Read ↗

cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse modelSemantic proximity Read ↗

Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signalingSemantic proximity Read ↗

ABCC1/MRP1 exports cGAMP and modulates cGAS-dependent immunitySemantic proximity Read ↗

Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling.Semantic proximity Read ↗

Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity.Semantic proximity Read ↗

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus.Semantic proximity Read ↗

Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and LupusSemantic proximity Read ↗

Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.