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Article

Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation.

Cell stem cell - 7 Sept 2017

Thomas Charles A, Tejwani Leon, Trujillo Cleber A, Negraes Priscilla D, Herai Roberto H, Mesci Pinar, Macia Angela, Crow Yanick J, Muotri Alysson R

Abstract excerpt

Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated inflammatory response. Autoimmune diseases, including Aicardi-Goutières syndrome (AGS) and systemic lupus erythematosus, can arise when TREX1 function is compromised. AGS is a neuroinflammatory disorder with severe and persistent...

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Identifiers

PMID: 28803918
DOI: 10.1016/j.stem.2017.07.009
PMCID: PMC5591075

Genes

TREX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation.PMID 28803918Read ↗

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