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Article

Modular double-stranded DNA recognition defines specificity of the exonuclease TREX1 in cGAS-STING control.

Immunity - 9 Jun 2026

Zhu Jiali, Wang Lei, Lin Changjie, Bian Shuchen, Luan Xiaohan, Sui Yingying, Piao Luhang, Zhou Wen

Abstract excerpt

TREX1, but not other DEDDh exonucleases, restrains cyclic GMP-AMP synthase- stimulator of interferon genes (cGAS-STING) activation by cytosolic DNA. Here, we examined the mechanisms underlying this specificity. Biochemical comparison of TREX1 and TREX2 mapped TREX1's ability to degrade dsDNA and suppress cGAS signaling to a single amino acid, R128. Metazoan TREX proteins containing an R128-equivalent functioned...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42034062
DOI: 10.1016/j.immuni.2026.03.025

Genes

TREX1
TREX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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