Article

Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling

2024-01-04

Abstract excerpt

<h4>ABSTRACT</h4> The cGAS-STING pathway detects cytosolic DNA and activates a signaling cascade that results in a type I interferon (IFN) response. The endoplasmic reticulum (ER)-associated exonuclease TREX1 suppresses cGAS-STING by eliminating DNA from the cytosol. Mutations that compromise TREX1 function are linked to autoinflammatory disorders, including systemic lupus erythematosus (SLE) and Aicardi-Goutière...

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Literature Corpus work: c6ce904f-4374-546c-9ac2-af44d9339c9a
DOI: 10.1101/2024.01.04.574136

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