High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus.

doi:10.1136/annrheumdis-2019-216227

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Article

High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Mar 2020

Reid Sarah, Alexsson Andrei, Frodlund Martina, Morris David, Sandling Johanna K, Bolin Karin, Svenungsson Elisabet, Jönsen Andreas, Bengtsson Christine, Gunnarsson Iva, Illescas Rodriguez Vera, Bengtsson Anders, Arve Sabine, Rantapää-Dahlqvist Solbritt, Eloranta Maija-Leena, Syvänen Ann-Christine, Sjöwall Christopher, Vyse Timothy James, Rönnblom Lars, Leonard Dag

Abstract excerpt

OBJECTIVES: To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE). METHODS: Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 200K Immunochip single nucleotide polymorphism array. A genetic risk score (GRS) was assigned to each individual...

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PMID: 31826855
DOI: 10.1136/annrheumdis-2019-216227
PMCID: PMC7034364

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