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Article

Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity.

Human molecular genetics - 27 Jun 2020

Chen Lingyan, Wang Yong-Fei, Liu Lu, Bielowka Adrianna, Ahmed Rahell, Zhang Huoru, Tombleson Phil, Roberts Amy L, Odhams Christopher A, Cunninghame Graham Deborah S, Zhang Xuejun, Yang Wanling, Vyse Timothy J, Morris David L

Abstract excerpt

Using three European and two Chinese genome-wide association studies (GWAS), we investigated the performance of genetic risk scores (GRSs) for predicting the susceptibility and severity of systemic lupus erythematosus (SLE), using renal disease as a proxy for severity. We used four GWASs to test the performance of GRS both cross validating within the European population and between European and Chinese...

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Identifiers

PMID: 32077931
DOI: 10.1093/hmg/ddaa030
PMCID: PMC7322569

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