Article
Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.
PLoS genetics - 1 Feb 2011
Taylor Kimberly E, Chung Sharon A, Graham Robert R, Ortmann Ward A, Lee Annette T, Langefeld Carl D, Jacob Chaim O, Kamboh M Ilyas, Alarcón-Riquelme Marta E, Tsao Betty P, Moser Kathy L, Gaffney Patrick M, Harley John B, Petri Michelle, Manzi Susan, Gregersen Peter K, Behrens Timothy W, Criswell Lindsey A
Abstract excerpt
Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. Recent studies have greatly expanded the number of established SLE risk alleles, but the distribution of multiple risk alleles in cases versus controls and their relationship to subphenotypes have not been studied. We studied 22 SLE susceptibility polymorphisms with previous genome-wide evidence of...
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