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Article

Polygenic Risk Score Predicts Earlier-Onset Adult Systemic Lupus Erythematosus and First-Year Renal Diseases in a Taiwanese Cohort.

RMD open - 18 Apr 2024

Chen Yen-Ju, Hsiao Tzu-Hung, Lin Ying-Cheng, Jeng Wen-Juei, Mao Chien-Lin, Wei Chia-Yi, Hsieh Yi-Chung, Huang Chih-Jen, Pan Mei-Hung, Chen I-Chieh, Lin Ching-Heng, Chen Yi-Ming, Yang Hwai-I

Abstract excerpt

OBJECTIVES: This study aimed to develop a predictive model using polygenic risk score (PRS) to forecast renal outcomes for adult systemic lupus erythematosus (SLE) in a Taiwanese population. METHODS: Patients with SLE (n=2782) and matched non-SLE controls (n=11 128) were genotyped using Genome-Wide TWB 2.0 single-nucleotide polymorphism (SNP) array. PRS models (C+T, LDpred2, Lassosum, PRSice-2, PRS-continuous...

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Identifiers

PMID: 38637112
DOI: 10.1136/rmdopen-2023-003293
PMCID: PMC11146410

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