Article
Genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains.
Atherosclerosis - 1 Jan 2020
Fuller Daniela T, Grainger Andrew T, Manichaikul Ani, Shi Weibin
Abstract excerpt
BACKGROUND AND AIMS: Oxidative stress is associated with cardiometabolic traits in observational studies, yet the underlying causal relationship remains unclear. Apolipoprotein E-deficient (Apoe-/-) mice develop significant hyperlipidemia and hyperglycemia on a Western diet. Here we conducted linkage analysis to investigate genetic connections between cardiometabolic traits and oxidative stress. METHODS: 266...
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