Article
Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains.
BMC genetics - 10 Nov 2015
Wang Qian, Grainger Andrew T, Manichaikul Ani, Farber Emily, Onengut-Gumuscu Suna, Shi Weibin
Abstract excerpt
BACKGROUND: Individuals with dyslipidemia often develop type 2 diabetes, and diabetic patients often have dyslipidemia. It remains to be determined whether there are genetic connections between the 2 disorders. METHODS: A female F2 cohort, generated from BALB/cJ (BALB) and SM/J (SM) Apoe-deficient (Apoe(-/-)) strains, was started on a Western diet at 6 weeks of age and maintained on the diet for 12 weeks. Fasting...
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