A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes.

doi:10.1093/hmg/ddy217

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Article

A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes.

Human molecular genetics - 1 Sept 2018

Vogel Heike, Kamitz Anne, Hallahan Nicole, Lebek Sandra, Schallschmidt Tanja, Jonas Wenke, Jähnert Markus, Gottmann Pascal, Zellner Lisa, Kanzleiter Timo, Damen Mareike, Altenhofen Delsi, Burkhardt Ralph, Renner Simone, Dahlhoff Maik, Wolf Eckhard, Müller Timo D, Blüher Matthias, Joost Hans-Georg, Chadt Alexandra, Al-Hasani Hadi, Schürmann Annette

Abstract excerpt

To explore the genetic determinants of obesity and Type 2 diabetes (T2D), the German Center for Diabetes Research (DZD) conducted crossbreedings of the obese and diabetes-prone New Zealand Obese mouse strain with four different lean strains (B6, DBA, C3H, 129P2) that vary in their susceptibility to develop T2D. Genome-wide linkage analyses localized more than 290 quantitative trait loci (QTL) for obesity, 190 QTL...

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PMID: 29893858
DOI: 10.1093/hmg/ddy217
PMCID: PMC6097155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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