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Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells

9 Dec 2019

Abstract excerpt

High levels and activity of Src kinase are common among breast cancer subtypes, and several inhibitors of the kinase are currently tested in clinical trials. Alterations in mitochondrial activity is also observed among the different types of breast cancer. Src kinase is localized in several subcellular compartments, including mitochondria where it targets several proteins to modulate the activity of the...

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PMID: 31819039
DOI: 10.1038/s41419-019-2134-8

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